Association Between 30 Day Villalta Scores and Long Term Post-Thrombotic Syndrome Incidence and Severity Following Acute Deep Vein Thrombosis

Post-thrombotic syndrome (PTS) is a major complication of deep vein thrombosis (DVT). Earlier identification of patients at the highest risk of developing PTS would reduce the operational burden of trials evaluating PTS treatment and allow for escalation of care before disease advancement. The 30 day Villalta score severity category has been shown to be a strong predictor of disease severity through 24 months, 1 Kahn S.R. Shrier I. Julian J.A. Ducruet T. Arsenault L. Miron M.J. et al. Determinants and time course of the postthrombotic syndrome after acute deep venous thrombosis. Ann Intern Med. 2008; 149: 698-707 Crossref PubMed Scopus (705) Google Scholar suggesting that early Villalta scores may be useful for identifying those at highest risk of developing PTS and be a meaningful outcome for clinical studies. Since it is unknown whether these findings are generalisable to patients receiving contemporary treatments, which include a wider variety of commercially available stents, approved anticoagulation agents, and diagnostic imaging modalities, the present analysis was conducted to determine whether 30 day Villalta scores in two large interventional DVT studies were similarly associated with disease severity at later time points.