睡眠剥夺
生物
睡眠(系统调用)
肠道菌群
人口
贫困
危害
粪便细菌疗法
医学
环境卫生
免疫学
神经科学
心理学
昼夜节律
社会心理学
微生物学
抗生素
计算机科学
艰难梭菌
操作系统
作者
Hongyu Chen,Chen Wang,Junying Bai,Jiajia Song,Linli Bu,Ming Liang,Huayi Suo
标识
DOI:10.1016/j.micres.2023.127467
摘要
Sleep deprivation has become a common health hazard, affecting 37-58% of the population and promoting the occurrence and development of many diseases. To date, effective treatment strategies are still elusive. Accumulating evidence indicates that modulating the intestinal microbiota harbors significant potential for alleviating the deleterious impacts of sleep deprivation. This paper first reviews the effects of sleep deprivation on gastrointestinal diseases, metabolic diseases, and neuropsychiatric diseases, discussing its specific mechanisms of influence. We then focus on summarizing existing interventions, including probiotics, melatonin, prebiotics, diet, and fecal microbiota transplantation (FMT). Finally, we have discussed the advantages and limitations of each strategy. Compared with other strategies, probiotics showed a high potential in alleviating sleep deprivation-related hazards due to their reduced risk and high security. We suggest that future research should focus on the specific mechanisms by which probiotics mitigate the harms of sleep deprivation, such insights may unveil novel pathways for treating diseases exacerbated by insufficient sleep.
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