生物
自噬
细胞生物学
蛋白激酶A
生物化学
死孢子体1
激酶
自噬体
雷帕霉素的作用靶点
PI3K/AKT/mTOR通路
信号转导
细胞凋亡
作者
Yuyao Feng,Ying Chen,Xiaoyong Wu,Junye Chen,Qingyan Zhou,Bao Liu,Liqin Zhang,Cong Yi
出处
期刊:Autophagy
[Informa]
日期:2023-08-18
卷期号:20 (1): 4-14
被引量:27
标识
DOI:10.1080/15548627.2023.2247300
摘要
Macroautophagy/autophagy, is widely recognized for its crucial role in enabling cell survival and maintaining cellular energy homeostasis during starvation or energy stress. Its regulation is intricately linked to cellular energy status. In this review, covering yeast, mammals, and plants, we aim to provide a comprehensive overview of the understanding of the roles and mechanisms of carbon- or glucose-deprivation related autophagy, showing how cells effectively respond to such challenges for survival. Further investigation is needed to determine the specific degraded substrates by autophagy during glucose or energy deprivation and the diverse roles and mechanisms during varying durations of energy starvation.
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