化学
试剂
指示
亚砜
硫黄
重氮甲烷
氯化物
组合化学
有机化学
分子
作者
Fumito Saito,Simon Euteneuer
出处
期刊:Organic Letters
[American Chemical Society]
日期:2023-08-08
卷期号:25 (32): 6057-6061
被引量:2
标识
DOI:10.1021/acs.orglett.3c02301
摘要
We report a one-pot, three-component synthesis of sulfides by exploiting a sulfoxide reagent as a formal sulfur dication equivalent. Our protocol consists of three simple chemical operations involving two Grignard reagents and trimethylsilyl chloride (TMSCl) to sequentially form sulfenate anions, sulfenate esters, and sulfides. We demonstrate a wide range of Grignard reagents to be coupled, thereby allowing the modular, thiol-free synthesis of sulfides including dialkenyl and alkenyl-alkynyl sulfides.
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