Smoking Affects the Post-Stroke Inflammatory Response of Lipid Mediators in a Gender-Related Manner

花生四烯酸 二十烷酸 医学 内科学 生理学 内分泌学 生物 生物化学
作者
Arleta Drozd,Dariusz Kotlęga,Krzysztof Dmytrów,Małgorzata Szczuko
出处
期刊:Biomedicines [Multidisciplinary Digital Publishing Institute]
卷期号:11 (1): 92-92
标识
DOI:10.3390/biomedicines11010092
摘要

The main goal of our study was to determine the effect of cigarette smoking on selected derivatives of arachidonic acid, linoleic acid, DHA, and EPA, which may be markers of post-stroke inflammation. The eicosanoid profile was compared in both smoking and non-smoking patients, without division and with division into gender. In the group of non-smokers, we observed higher levels of the linolenic acid derivative (LA) 9S HODE (p ≤ 0.05) than in smokers. However, after dividing the results by sex, it turned out that the level of this derivative was higher in non-smoking women compared to smoking women (p ≤ 0.01) and did not differentiate the group of men. Similarly, the level of the arachidonic acid metabolite LTX A4 (p ≤ 0.05) differed only in the group of women. In this group, we also observed a decreased level of 15S HETE in smoking women, but it was statistically insignificant (p ≤ 0.08). On the other hand, the level of this derivative was statistically significantly higher in the group of non-smoking women compared to male non-smokers. The group of men was differentiated by two compounds: TXB2 and NPD1. Male smokers had an almost two-fold elevation of TXB2 (p ≤ 0.01) compared with non-smokers, and in this group, we also observed an increased level of NPD1 compared with male non-smokers. On the other hand, when comparing female non-smokers and male non-smokers, in addition to the difference in 15S HETE levels, we also observed elevated levels of TXB2 in the group of non-smokers. We also analyzed a number of statistically significant correlations between the analyzed groups. Generally, men and women smokers showed a much smaller amount of statistically significant correlations than non-smokers. We believe that this is related to the varying degrees of inflammation associated with acute ischemic stroke and post-stroke response. On the one hand, tobacco smoke inhibits the activity of enzymes responsible for the conversion of fatty acids, but on the other hand, it can cause the failure of the inflammatory system, which is also the body's defense mechanism. Smoking cigarettes is a factor that increases oxidative stress even before the occurrence of a stroke incident, and at the same time accelerates it and inhibits post-stroke repair mechanisms. This study highlights the effect of smoking on inflammation in both genders mediated by lipid mediators, which makes smoking cessation undeniable.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
GXSH发布了新的文献求助10
1秒前
1秒前
所所应助超帅的成败采纳,获得10
1秒前
爬山虎发布了新的文献求助10
1秒前
shaoshao86完成签到,获得积分10
2秒前
如意的刚应助路路采纳,获得10
3秒前
o30发布了新的文献求助10
3秒前
柳易关注了科研通微信公众号
3秒前
张乐渝发布了新的文献求助10
3秒前
凉凉盛夏完成签到,获得积分10
3秒前
芋泥乎乎完成签到,获得积分10
4秒前
4秒前
bkagyin应助追寻绮玉采纳,获得10
5秒前
5秒前
LiAlan发布了新的文献求助10
6秒前
小钟发布了新的文献求助10
6秒前
Stove完成签到,获得积分10
6秒前
CodeCraft应助1234采纳,获得10
6秒前
ludong_0应助ccc采纳,获得10
7秒前
ZXW完成签到,获得积分10
7秒前
十一点还没学习完成签到 ,获得积分10
7秒前
7秒前
WLL完成签到,获得积分10
7秒前
小青发布了新的文献求助10
7秒前
7秒前
8秒前
疚祠完成签到,获得积分10
8秒前
Ferry完成签到 ,获得积分10
9秒前
欣慰碧琴完成签到,获得积分10
9秒前
9秒前
zzzzz完成签到,获得积分10
10秒前
10秒前
10秒前
11秒前
11秒前
11秒前
自然的雁蓉完成签到,获得积分10
11秒前
11秒前
糊涂的元珊完成签到 ,获得积分10
12秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Picture Books with Same-sex Parented Families: Unintentional Censorship 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3969094
求助须知:如何正确求助?哪些是违规求助? 3514055
关于积分的说明 11171564
捐赠科研通 3249344
什么是DOI,文献DOI怎么找? 1794799
邀请新用户注册赠送积分活动 875377
科研通“疑难数据库(出版商)”最低求助积分说明 804779