Transition Metal-Catalyzed Asymmetric Cyclizations Involving Allyl or Propargyl Heteroatom-Dipole Precursors

Chiral heterocyclic compounds are an important class of chiral substances, which are widespread in many chiral drugs, pesticides and catalysts.Therefore, the efficient asymmetric synthesis of these compounds becomes a research hotspot in organic synthesis.Transition metal-catalyzed asymmetric cyclization with heteroatom-dipole precursors is an important method to construct these frameworks.Among them, the heteroatom-dipole precursors designed based on transition metal-catalyzed allyl or propargyl substitutions have been extensively studied in the past two decades and occupied an important role in this field.The transition metal-catalyzed asymmetric cyclizations with allyl or propargyl heteroatom-dipole precursors are introduced in detail.The advantages and existing problems of the current methods are analyzed, which would provide useful reference for the researchers in asymmetric synthesis and related fields.