Impact of CAD-CAM materials and bonding protocol on the bond strength between denture base/artificial teeth: a systematic review and meta-analysis

To identify the most effective bonding protocol between the denture base and artificial teeth made with different CAD/CAM materials (milled and 3D printed) compared to conventional heat-cured materials.This review was performed according to the Preferred Reporting Items for Systematic and Meta-Analysis (PRISMA) criteria and registered in PROSPERO (CRD42021276084). An electronic search was performed independently by two examiners in the MEDLINE/PubMed, Cochrane Library, Scopus, Web of Science, ProQuest, and OpenGrey databases for articles published up to and including December 2021.The electronic search returned 806 articles, and after duplicates were removed, the total was 589 articles. Four articles were selected according to the eligibility criteria. Evaluating the different combinations of denture base materials and artificial teeth, the IvoBase CAD Bond (Ivoclar Vivadent) was effective for bonding the CAD/CAM denture bases to prefabricated acrylic resin denture artificial teeth. There were no differences compared to heat-cured denture base bonding to prefabricated acrylic resin denture artificial teeth (χ2: 68.56; I2: 96%; P < .001).IvoBase CAD Bond as a bonding system can be an alternative for using new technologies in the fabrication of α CAD/CAM base with prefabricated acrylic resin denture artificial teeth.