Prognostic impacts of Lipoxin A4 in patients with acute myocardial infarction: A prospective cohort study

狼牙棒 医学 危险系数 心肌梗塞 内科学 前瞻性队列研究 置信区间 生物标志物 比例危险模型 心脏病学 经皮冠状动脉介入治疗 生物化学 化学
作者
Runzhen Chen,Jiannan Li,Jinying Zhou,Ying Wang,Xiaoxiao Zhao,Nan Li,Weida Liu,Chen Liu,Peng Zhou,Yi Chen,Shangyao Yan,Li Song,Hongbing Yan,Hanjun Zhao
出处
期刊:Pharmacological Research [Elsevier]
卷期号:187: 106618-106618
标识
DOI:10.1016/j.phrs.2022.106618
摘要

Lipoxin A4 (LXA4) is one of the specialized pro-resolving lipid mediators proved to suppress the progression of atherosclerosis in vivo, but its clinical impacts in atherosclerotic patients is unclear. In this study, we assessed the prognostic impacts of LXA4 in patients with acute myocardial infarction (AMI). A total of 1569 consecutive AMI patients were prospectively recruited from March 2017 to January 2020. Plasma samples of AMI patients were collected, and LXA4 levels were determined using enzyme-linked immunosorbent assay. The primary outcome was major adverse cardiovascular event (MACE), a composite of all-cause death, recurrent MI, ischemic stroke, or ischemia-driven revascularization. Cox regression was used to assess associations between LXA4 and clinical outcomes. Overall, the median level of LXA4 was 5.637 (3.047-9.014) ng/mL for AMI patients. During a median follow-up of 786 (726-1108) days, high LXA4 (≥ 5.637 ng/mL) was associated with lower risk of MACE (hazard ratio [HR]: 0.73, 95% confidence interval [CI]: 0.60-0.89, P = 0.002), which was sustained in propensity score matching (HR: 0.73, 95% CI: 0.60-0.90, P = 0.004) and inverse probability weighting analysis (HR: 0.74, 95% CI: 0.61-0.90, P = 0.002). Combined with pro-inflammatory biomarker, patients with high levels of LXA4 (≥ 5.637 ng/mL) but low levels of high-sensitivity C-reactive protein (< 5.7 mg/L) acquired the lowest risk of MACE (HR: 0.68, 95% CI: 0.51-0.92, P = 0.012). In sum, high levels of LXA4 were associated with lower risk of recurrent ischemic events for AMI patients, which could serve as new therapeutic target to tackle cardiovascular inflammation.
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