以兹提米比
阿托伐他汀
生物分析
色谱法
高脂血症
化学
萃取(化学)
液相色谱-质谱法
药理学
医学
质谱法
胆固醇
生物化学
内分泌学
糖尿病
作者
Ehab F. Elkady,Bushra Mohammed Jaadan,Elsayed Ramadan,Ayman Abo Elmaaty
出处
期刊:Bioanalysis
[Newlands Press Ltd]
日期:2022-11-01
卷期号:14 (21): 1349-1363
被引量:1
标识
DOI:10.4155/bio-2022-0203
摘要
Background: Hyperlipidemia is one of the most common chronic diseases encountered globally, and atorvastatin (ATV) is mainly metabolized into two major active metabolites. Methodology: Hence, we aimed to estimate ATV and ezetimibe (EZE) simultaneously in the presence of ATV major and active metabolites using a validated LC-MS/MS method. Conclusion: The proposed method was linear (r2 >0.99), accurate (92.02-109.94%) and precise (CV% ≤14) over the concentration range of 0.50-120 ng/ml, 0.20-48 ng/ml, 0.50-120 ng/ml and 0.20-48 ng/ml for ATV, EZE, 2-hydroxy ATV and 4-hydroxy ATV, respectively. The applied liquid-liquid extraction gave rise to reliable extraction recoveries of 84.91 ± 1.14%, 85.20 ± 1.62%, 85.46 ± 0.41% and 105.46 ± 2.35% for ATV, EZE, 2-hydroxy ATV and 4-hydroxy ATV, respectively.
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