电流(流体)
癌症治疗
癌症医学
癌症
精密医学
纳米技术
医学
材料科学
医学物理学
电气工程
内科学
病理
工程类
作者
Zheng Li,Jianhua Zou,Xiaoyuan Chen
标识
DOI:10.1002/adma.202209529
摘要
Abstract Emerging as a potent anticancer treatment, subcellular targeted cancer therapy has drawn increasing attention, bringing great opportunities for clinical application. Here, two targeting strategies for four main subcellular organelles (mitochondria, lysosome, endoplasmic reticulum, and nucleus), including molecule‐ and nanomaterial (inorganic nanoparticles, micelles, organic polymers, and others)‐based targeted delivery or therapeutic strategies, are summarized. Phototherapy, chemotherapy, radiotherapy, immunotherapy, and “all‐in‐one” combination therapy are among the strategies covered in detail. Such materials are constructed based on the specific properties and relevant mechanisms of organelles, enabling the elimination of tumors by inducing dysfunction in the corresponding organelles or destroying specific structures. The challenges faced by organelle‐targeting cancer therapies are also summarized. Looking forward, a paradigm for organelle‐targeting therapy with enhanced therapeutic efficacy compared to current clinical approaches is envisioned.
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