已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Glucose intolerance in pregnancy and risk of early-onset type 2 diabetes: a population-based cohort study

医学 妊娠期糖尿病 2型糖尿病 危险系数 人口 糖尿病 队列 队列研究 怀孕 比例危险模型 内科学 产科 内分泌学 妊娠期 置信区间 环境卫生 遗传学 生物
作者
Aya Bardugo,Cole D. Bendor,Ran Rotem,Avishai M. Tsur,Estela Derazne,Hertzel C. Gerstein,Dorit Tzur,Orit Pinhas‐Hamiel,Tali Cukierman‐Yaffe,Itamar Raz,Moshe Hod,Amir Tirosh,Yael Lebenthal,Arnon Afek,Gabriel Chodick,Gilad Twig
出处
期刊:The Lancet Diabetes & Endocrinology [Elsevier BV]
卷期号:11 (5): 333-344 被引量:20
标识
DOI:10.1016/s2213-8587(23)00062-1
摘要

The risk of type 2 diabetes among women with glucose intolerance during pregnancy that does not meet gestational diabetes criteria requires further investigation. We aimed to explore the associations between various degrees of gestational glucose intolerance and the risk of type 2 diabetes in young adulthood.For this population-based cohort study, the national Israeli conscription database was linked to Maccabi Healthcare Services (MHS), the second-largest state-mandated health provider in Israel. We included 177 241 women who underwent a pre-recruitment evaluation at adolescence (age 16-20 years), 1 year before mandatory military service, and later underwent, from Jan 1, 2001, to Dec 31, 2019, two-step gestational diabetes screening with a 50 g glucose challenge test (GCT) based on a threshold of 140 mg/dL (7·8 mmol/L), followed as needed by a 100 g oral glucose tolerance test (OGTT). Abnormal OGTT values were defined according to the Carpenter-Coustan thresholds: 95 mg/dL (5·3 mmol/L) or higher in the fasting state; 180 mg/dL (10·0 mmol/L) or higher at 1 h; 155 mg/dL (8·6 mmol/L) or higher at 2 h; and 140 mg/dL (7·8 mmol/L) or higher at 3 h. The primary outcome was incident type 2 diabetes in the MHS diabetes registry. Cox proportional hazards models were applied to estimate adjusted hazard ratios (HRs) with 95% CIs for incident type 2 diabetes.During a cumulative follow-up of 1 882 647 person-years, and with a median follow-up of 10·8 (IQR 5·2-16·4) years, 1262 women were diagnosed with type 2 diabetes. Crude incidence rates of type 2 diabetes were 2·6 (95% CI 2·4-2·9) per 10 000 person-years in women with gestational normoglycaemia, 8·9 (7·4-10·6) per 10 000 person-years in women with an abnormal GCT and normal OGTT, 26·1 (22·4-30·1) per 10 000 person-years in women with one abnormal OGTT value (in the fasting state or 1 h, 2 h, or 3 h post-challenge), and 71·9 (66·0-78·3) per 10 000 person-years in women with gestational diabetes. After adjustment for sociodemographic characteristics, adolescent BMI, and age at gestational screening, the risk of type 2 diabetes was higher, compared to the gestational normoglycaemia group, in women with an abnormal GCT and normal OGTT (adjusted hazard ratio [HR] 3·39 [95% CI 2·77-4·16]; p<0·0001), in women with one abnormal OGTT value (9·11 [7·64-10·86]; p<0·0001), and in women with gestational diabetes (24·84 [21·78-28·34]; p<0·0001). The risk of type 2 diabetes was modestly increased in women with isolated elevated fasting glucose (adjusted HR 11·81 [95% CI 8·58-16·25]; p<0·0001), and in women with gestational diabetes and an abnormal fasting glucose (38·02 [32·41-44·61]; p<0·0001).Gestational glucose intolerance, including conditions not meeting gestational diabetes criteria of the two-step strategy, confers a high risk of type 2 diabetes in young adulthood. These conditions should be recognised as risk factors for type 2 diabetes, especially among women with abnormal fasting glucose concentrations during pregnancy.None.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Angela完成签到,获得积分10
7秒前
betyby完成签到 ,获得积分10
7秒前
sudor123456完成签到,获得积分10
8秒前
隐形曼青应助饭ff采纳,获得10
8秒前
ddfighting完成签到,获得积分10
9秒前
迷人兰花完成签到,获得积分10
18秒前
ab完成签到,获得积分10
23秒前
瘦瘦乌龟完成签到 ,获得积分10
29秒前
Worenxian完成签到 ,获得积分10
30秒前
冰西瓜完成签到 ,获得积分0
32秒前
SYLH应助ceeray23采纳,获得20
34秒前
Owen应助科研达人采纳,获得10
39秒前
杨程羽发布了新的文献求助10
43秒前
孤标傲世完成签到 ,获得积分10
44秒前
魔幻安南完成签到 ,获得积分10
45秒前
pp‘s完成签到 ,获得积分10
50秒前
大学生完成签到 ,获得积分10
53秒前
杨程羽完成签到 ,获得积分10
59秒前
仙女完成签到 ,获得积分10
59秒前
传奇3应助LMX采纳,获得10
1分钟前
linghu完成签到 ,获得积分10
1分钟前
Tendency完成签到 ,获得积分10
1分钟前
善学以致用应助皮皮蟹采纳,获得10
1分钟前
1分钟前
1分钟前
1分钟前
小小斌完成签到,获得积分10
1分钟前
LMX发布了新的文献求助10
1分钟前
1分钟前
1分钟前
yang完成签到 ,获得积分10
1分钟前
沉静安荷给沉静安荷的求助进行了留言
1分钟前
皮皮蟹发布了新的文献求助10
1分钟前
轻松的惜芹应助科研达人采纳,获得10
1分钟前
广州小肥羊完成签到 ,获得积分10
1分钟前
皮皮蟹完成签到,获得积分10
1分钟前
完美世界应助ceeray23采纳,获得20
1分钟前
曾经的电脑完成签到 ,获得积分10
1分钟前
Sky完成签到,获得积分10
1分钟前
握瑾怀瑜完成签到 ,获得积分0
1分钟前
高分求助中
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3990012
求助须知:如何正确求助?哪些是违规求助? 3532047
关于积分的说明 11256141
捐赠科研通 3270918
什么是DOI,文献DOI怎么找? 1805105
邀请新用户注册赠送积分活动 882270
科研通“疑难数据库(出版商)”最低求助积分说明 809216