The reversed De Ritis ratio for predicting in-hospital mortality among intensive care patients with organophosphate poisoning

医学 有机磷中毒 格拉斯哥昏迷指数 内科学 危险系数 重症监护室 胃肠病学 丙氨酸转氨酶 丙氨酸转氨酶 有机磷 外科 置信区间 杀虫剂 农学 生物
作者
Ola Elsayed Nafea,Fatma Ibrahim,Walaa G. Abdelhamid
出处
期刊:Biomarkers [Taylor & Francis]
卷期号:28 (1): 111-117 被引量:1
标识
DOI:10.1080/1354750x.2022.2148746
摘要

The uncontrolled use of pesticides signifies a substantial health hazard. This study was designed to explore the prognostic role of on-admission hepatic aminotransferases [alanine aminotransferase (ALT) and aspartate aminotransferase (AST), and the reversed De Ritis ratio (ALT/AST)] in the prediction of in-hospital mortality among patients with acute organophosphate (OP) poisoning.We conducted a retrospective study based on extracting the required information from the specific medical records for acutely OP-intoxicated patients admitted to the intensive care unit.A total of 49 acutely malathion-intoxicated patients were enrolled in the study. The in-hospital mortality rate was 32.7%. Patients were stratified into survivors and non-survivors. Compared to the survivors, the non-survivors had significantly lower Glasgow coma scale scores, mean arterial blood pressure, significantly higher reversed De Ritis ratio (ALT/AST), and ALT and AST activities. The reversed De Ritis ratio (ALT/AST) and ALT demonstrated good discrimination between the survivors and the non-survivors with an area under the curve (AUC) of 0.708 vs 0.781, respectively, however, AST showed satisfactory discrimination, AUC of 0.694.Hepatic aminotransferases are useful in predicting in-hospital mortality in acute OP poisoning. ALT is the most specific biomarker. However, the reversed De Ritis ratio (ALT/AST) is the most sensitive one.
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