化学
三氟甲基
硅烷化
催化作用
乙醚
组合化学
有机化学
光化学
烷基
作者
Shafrizal Rasyid Atriardi,Jae‐Young Kim,Yulia Anita,Sang Kook Woo
摘要
Abstract Herein, we present a novel method for the synthesis of gem ‐difluoroalkenes via visible‐light photoredox‐catalyzed defluoroaryloxymethylation of α‐trifluoromethyl alkenes using α‐silyl ethers as aryloxymethyl radical precursors. This reaction shows good functional group tolerance and provides the desired products in good to excellent yields. Based on mechanistic studies, we propose a reaction mechanism involving single‐electron oxidation of an α‐silyl ether to generate an α‐aryloxymethyl radical.
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