Coassembly of Dual-Modulated AIE-ESIPT Photosensitizers and UCNPs for Enhanced NIR-Excited Photodynamic Therapy

Aggregation-induced emission (AIE) photosensitizers are promising for photodynamic therapy, yet their short excitation wavelengths present a limitation. In this study, we develop a series of organic photosensitizers with dual modulation capabilities based on excited-state intramolecular proton transfer (ESIPT) and AIE. Notably, we synthesize near-infrared (NIR)-excited photosensitive nanoparticles through a coassembly strategy utilizing upconversion nanoparticles (UCNPs) and amphiphilic polymers. The spectroscopic analysis and theoretical calculations elucidate the significant impact of additional or π-spacer groups on the conformational change and the energy barrier of the ESIPT process. An efficient Förster resonance energy transfer between the photosensitizer and UCNPs is achieved through the coassembly strategy. Both