Fusarolides A–C, Three Pyran-Macrolide Hybrids from a Marine Derived Fungal Fusarium verticillioide G102 as Asialoglycoprotein receptor 1 Inhibitor and Phytopathogenic Fungicides

Three undescribed 20-membered macrolides, fusarolides A-C (1-3), with relatively rare pyran-macrolide structures and complex chiral centers, were isolated from a marine derived fungal Fusarium verticillioide G102. Their chemical structures and stereoconfigurations were well elaborated. Compound 1 promoted cholesterol efflux from Huh-7 cells in a concentration-dependent manner by inhibiting Asialoglycoprotein receptor 1 (ASGR1), which was identified as a new therapeutic target in hypercholesterolemia in liver. Besides, compounds 1-3 exhibited obvious anti-phytopathogenic fungal activities.