Intraoperative Tranexamic Acid in Radical Cystectomy: Impact on Bleeding, Thromboembolism, and Survival Outcomes

Perioperative blood transfusion has been reported in > 50% of patients undergoing Radical cystectomy (RC). Unfortunately, perioperative blood transfusion in patients undergoing RC has been associated with poor oncological outcomes. Tranexamic acid (TXA) use has been proposed to decrease the need for perioperative blood transfusion. Here, we seek to investigate the impact of intraoperative TXA on the risk of perioperative bleeding and VTE in patients undergoing radical cystectomy (RC). We also investigate its long-term impact on overall survival (OS) and cancer-specific survival outcomes (CSS).