Altered regional brain activity moderating the relationship between childhood trauma and depression severity

CTQ树 哈姆德 重性抑郁障碍 萧条(经济学) 评定量表 临床心理学 医学 生物标志物 内科学 心理学 大脑活动与冥想 精神科 毒物控制 发展心理学 伤害预防 心情 脑电图 经济 家庭暴力 化学 宏观经济学 环境卫生 生物化学
作者
Zhanjie Luo,Weicheng Li,Fan Zhang,Zhibo Hu,Zerui You,Chengyu Wang,Xiaofeng Lan,Siming Mai,Xiaoyu Chen,Yexian Zeng,Yiying Chen,Yanmei Liang,Yifang Chen,Yanling Zhou,Yuping Ning
出处
期刊:Journal of Affective Disorders [Elsevier BV]
卷期号:351: 211-219 被引量:2
标识
DOI:10.1016/j.jad.2024.01.162
摘要

Childhood trauma (CT) is a major environmental risk factor for an adverse course and treatment outcome of major depressive disorder (MDD). Evidence suggests that an altered regional brain activity may play a crucial role in the relationship between CT and MDD. This study aimed to clarify the relationship between CT, regional brain activity, and depression severity. In this study, 96 patients with MDD and 82 healthy controls (HCs) participated. Regional brain activity was measured using the fractional amplitude of low-frequency fluctuation (fALFF) and regional homogeneity (ReHo). These measures were compared between the MDD and HC groups, and the values of different brain regions were extracted as moderators. Increased fALFF and ReHo values were observed in the left middle temporal gyrus in the MDD group compared with the HC group (p < 0.001). Furthermore, the fALFF and ReHo values moderated the positive correlation between the Childhood Trauma Questionnaire (CTQ) score, 17-item Hamilton Depression Rating Scale (HAMD-17) total score, and retardation factor score in the MDD group (all, p < 0.05). Finally, as the fALFF and ReHo values increased, the positive correlations between CTQ, HAMD-17 total, and retardation dimension scores became stronger. Our study highlighted the crucial role of altered brain function in connecting childhood maltreatment with depressive symptoms. Our findings indicate that an altered regional brain activity could explain the potential neurobiological mechanisms of MDD symptoms, offering the opportunity to function as a powerful diagnostic biomarker.
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