Comparative Dissolution of Budesonide from Four Commercially Available Products for Oral Administration: Implications for Interchangeablity

Budesonide is a corticosteroid regularly used in oral formulations to treat various inflammatory diseases in the gastrointestinal tract, such as Crohn's disease and ulcerative colitis.Budesonide has also been formulated to be effective against immunoglobulin A (IgA)-related nephropathy.This study aimed to compare the release of budesonide from four oral formulations under discriminating dissolution conditions to ascertain if they are interchangeable.Each product had a unique dissolution profile along with differences in indications, doses, and dosing conditions.As such, there is no basis for considering the tested products to be pharmaceutically or therapeutically interchangeable.