细胞周期蛋白依赖激酶2
细胞周期蛋白依赖激酶
细胞周期
化学
癌症治疗
激酶
癌症研究
癌症
细胞周期蛋白
细胞生物学
细胞
计算生物学
生物化学
生物
遗传学
作者
Dharmesh A. Patel,Siddharth S. Patel,Hitesh D. Patel
标识
DOI:10.1016/j.bioorg.2023.107045
摘要
One of the leading causes of mortality in the world is cancer. This disease occurs when responsible genes that regulate the cell cycle become inactive due to internal or external factors. Specifically, the G1/S and S/G2 transitions in the cell cycle are controlled by a protein called cyclin-dependent kinase 2 (CDK2). CDKs, which play a crucial role in managing the cell cycle, have been a wide area of research in cancer treatment. Over the past 11 years, significant research has been made in identifying potent, targeted, and efficient inhibitors of CDK2. In this summary, we have summarized recent developments in the synthesis and biological evaluation of CDK2 inhibitors.
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