免疫抑制
医学
肾移植
重症监护医学
移植
肺炎
呼吸道感染
免疫学
泌尿系统
内科学
呼吸系统
作者
Joyita Bharati,Urmila Anandh,Camille N. Kotton,Nicolas J. Mueller,Aakash Shingada,Raja Ramachandran
标识
DOI:10.1016/j.semnephrol.2023.151486
摘要
Summary
Kidney transplant often is complicated by infections in the recipient from therapy-related and patient-related risk factors. Infections in kidney transplant recipients are associated with increased morbidity, mortality, and allograft dysfunction. There is a predictable timeline after kidney transplant regarding the types of pathogens causing infections, reflecting the net state of immunosuppression. In the early post-transplant period, bacterial infections comprise two thirds of all infections, followed by viral and fungal infections. Infections occurring early after kidney transplantation are generally the result of postoperative complications. In most cases, opportunistic infections occur within 6 months after kidney transplantation. They may be caused by a new infection, a donor-derived infection, or reactivation of a latent infection. Community-acquired pneumonia, upper respiratory tract infections, urinary tract infections, and gastrointestinal infections are the most common infections in the late period after transplantation when the net immunosuppression is minimal. It is crucial to seek information on the time after transplant, reflecting the net state of immunosuppression, previous history of exposure/infections, geography, and seasonal outbreaks. It is imperative that we develop regionally specific guidelines on screening, prevention, and management of infections after kidney transplantation.
科研通智能强力驱动
Strongly Powered by AbleSci AI