细胞
细胞生物学
免疫疗法
过继性细胞移植
T细胞
细胞疗法
CD8型
癌症免疫疗法
细胞毒性T细胞
化学
癌症研究
免疫系统
生物
免疫学
生物化学
干细胞
体外
作者
Xinran Wang,Lu Lu,Xiaochuan Hong,Lingling Wu,Chao Yang,You Wang,Wenwen Li,Yuanqin Yang,Dongqing Cao,Wen Di,Liufu Deng
出处
期刊:Cell Reports
[Elsevier]
日期:2024-01-30
卷期号:43 (2): 113712-113712
被引量:1
标识
DOI:10.1016/j.celrep.2024.113712
摘要
Adoptive cell therapies are emerging forms of immunotherapy that reprogram T cells for enhanced antitumor responses. Although surface programmed cell death-ligand 1 (PD-L1)/programmed cell death protein 1 (PD-1) engagement inhibits antitumor immunity, the role of cell-intrinsic PD-L1 in adoptive T cell therapy remains unknown. Here, we found that intracellular PD-L1 was enriched in tumor-infiltrating CD8
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