A fast method for the determination of personal care product chemicals in human urine using dispersive liquid–liquid extraction and ultra high‐performance liquid chromatography–tandem mass spectrometry

色谱法 尿 液相色谱-质谱法 萃取(化学) 化学 检出限 质谱法 基质(化学分析) 高效液相色谱法 串联质谱法 生物化学
作者
Yawen Zheng,Yarui Liu,Zining Zhang,Liting Hua,Jing Fang,Lei Wang,Hongzhi Zhao
出处
期刊:Rapid Communications in Mass Spectrometry [Wiley]
卷期号:38 (5) 被引量:2
标识
DOI:10.1002/rcm.9684
摘要

Rationale Personal care product chemicals (PCPCs) are the chemicals used in personal care products. Many of them are endocrine disruptors and have potential adverse effects on humans. The concentrations of PCPCs in urine are the main biomarker for assessing human exposure. Methods A method was developed for the simultaneous determination of 14 PCPCs in human urine using dispersive liquid–liquid extraction combined with ultra high‐performance liquid chromatography–tandem mass spectrometry (UHPLC–MS/MS). Results Compared with liquid–liquid extraction, this method had the advantages of time efficiency, sensitivity, and limited organic solvent consumption. It produced good linearity (0.9965–0.9996), limits of detection (2.82–36.36 pg mL −1 ), limits of quantitation (9.39–121.08 pg mL −1 ), matrix effect (−0.90%–2.55%), intra‐day precision (relative standard deviations [RSDs] <15%), and inter‐day precision (RSDs <19.9%). The method had satisfactory relative recovery at three concentration levels. Conclusions A rapid method was developed for the simultaneous quantification of 14 PCPCs in human urine. The practicability of the method was verified with 21 urine from university students. It is expected that this method will provide a powerful reference for the assessment of exposure to PCPCs in large populations.
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