亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Association of LI-RADS and Histopathologic Features with Survival in Patients with Solitary Resected Hepatocellular Carcinoma

医学 肝细胞癌 危险系数 比例危险模型 倾向得分匹配 回顾性队列研究 磁共振成像 生存分析 置信区间 放射科 胃肠病学 内科学
作者
Roberto Cannella,Francesco Matteini,Marco Dioguardi Burgio,Riccardo Sartoris,Aurélie Beaufrère,Julien Caldéraro,Sebastien Mulé,Edouard Reizine,Alain Luciani,Alexis Laurent,Olivier Séror,Nathalie Ganne‐Carrié,Mathilde Wagner,Olivier Scatton,Valérie Vilgrain,François Cauchy,Christian Hobeika,Maxime Ronot
出处
期刊:Radiology [Radiological Society of North America]
卷期号:310 (2) 被引量:2
标识
DOI:10.1148/radiol.231160
摘要

Background Both Liver Imaging Reporting and Data System (LI-RADS) and histopathologic features provide prognostic information in patients with hepatocellular carcinoma (HCC), but whether LI-RADS is independently associated with survival is uncertain. Purpose To assess the association of LI-RADS categories and features with survival outcomes in patients with solitary resected HCC. Materials and Methods This retrospective study included patients with solitary resected HCC from three institutions examined with preoperative contrast-enhanced CT and/or MRI between January 2008 and December 2019. Three independent readers evaluated the LI-RADS version 2018 categories and features. Histopathologic features including World Health Organization tumor grade, microvascular and macrovascular invasion, satellite nodules, and tumor capsule were recorded. Overall survival and disease-free survival were assessed with Cox regression models. Marginal effects of nontargetoid features on survival were estimated using propensity score matching. Results A total of 360 patients (median age, 64 years [IQR, 56–70 years]; 280 male patients) were included. At CT and MRI, the LI-RADS LR-M category was associated with increased risk of recurrence (CT: hazard ratio [HR] = 1.83 [95% CI: 1.26, 2.66], P = .001; MRI: HR = 2.22 [95% CI: 1.56, 3.16], P < .001) and death (CT: HR = 2.47 [95% CI: 1.72, 3.55], P < .001; MRI: HR = 1.80 [95% CI: 1.32, 2.46], P < .001) independently of histopathologic features. The presence of at least one nontargetoid feature was associated with an increased risk of recurrence (CT: HR = 1.80 [95% CI: 1.36, 2.38], P < .001; MRI: HR = 1.93 [95% CI: 1.81, 2.06], P < .001) and death (CT: HR = 1.51 [95% CI: 1.10, 2.07], P < .010) independently of histopathologic features. In matched samples, recurrence was associated with the presence of at least one nontargetoid feature at CT (HR = 2.06 [95% CI: 1.15, 3.66]; P = .02) or MRI (HR = 1.79 [95% CI: 1.01, 3.20]; P = .048). Conclusion In patients with solitary resected HCC, LR-M category and nontargetoid features were negatively associated with survival independently of histopathologic characteristics. © RSNA, 2024 Supplemental material is available for this article. See also the editorial by Kartalis and Grigoriadis in this issue.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
小二郎应助科研通管家采纳,获得10
4秒前
4秒前
嗯哼应助科研通管家采纳,获得10
4秒前
mermer发布了新的文献求助10
8秒前
11秒前
16秒前
三叔发布了新的文献求助10
23秒前
聪明的小海豚完成签到,获得积分20
28秒前
科研通AI2S应助健康的绮南采纳,获得10
28秒前
三叔完成签到,获得积分0
31秒前
48秒前
52秒前
zhl完成签到,获得积分10
1分钟前
田様应助lewe采纳,获得10
1分钟前
个性小海豚完成签到 ,获得积分10
1分钟前
zero发布了新的文献求助10
1分钟前
嘎嘎的鸡神完成签到,获得积分10
2分钟前
黑桃完成签到,获得积分10
2分钟前
阔达碧空发布了新的文献求助10
2分钟前
3分钟前
方方99完成签到 ,获得积分0
3分钟前
FashionBoy应助XYF采纳,获得10
3分钟前
嗯哼应助科研通管家采纳,获得10
4分钟前
嗯哼应助科研通管家采纳,获得10
4分钟前
4分钟前
情怀应助Yx采纳,获得10
4分钟前
XYF发布了新的文献求助10
4分钟前
4分钟前
Yx发布了新的文献求助10
4分钟前
5分钟前
lewe发布了新的文献求助10
5分钟前
小马甲应助安慧娜采纳,获得10
5分钟前
嗯哼应助科研通管家采纳,获得10
6分钟前
嗯哼应助科研通管家采纳,获得10
6分钟前
嗯哼应助科研通管家采纳,获得10
6分钟前
嗯哼应助科研通管家采纳,获得10
6分钟前
香蕉觅云应助阔达碧空采纳,获得10
6分钟前
CipherSage应助科研通管家采纳,获得10
6分钟前
研友_VZG7GZ应助科研通管家采纳,获得10
6分钟前
嗯哼应助科研通管家采纳,获得10
6分钟前
高分求助中
求助这个网站里的问题集 1000
Floxuridine; Third Edition 1000
Tracking and Data Fusion: A Handbook of Algorithms 1000
La décision juridictionnelle 800
Rechtsphilosophie und Rechtstheorie 800
求口腔牙齿松动病症相关外文书籍2-3本 500
Academic entitlement: Adapting the equity preference questionnaire for a university setting 500
热门求助领域 (近24小时)
化学 医学 材料科学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 物理化学 催化作用 免疫学 细胞生物学 电极
热门帖子
关注 科研通微信公众号,转发送积分 2868545
求助须知:如何正确求助?哪些是违规求助? 2475978
关于积分的说明 6712108
捐赠科研通 2163770
什么是DOI,文献DOI怎么找? 1149693
版权声明 585565
科研通“疑难数据库(出版商)”最低求助积分说明 564474