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Apoptotic cell death in disease—Current understanding of the NCCD 2023

细胞凋亡 程序性细胞死亡 蛋白酵素 生物 背景(考古学) 癌变 平衡 细胞生物学 疾病 半胱氨酸蛋白酶 细胞 胚胎干细胞 神经退行性变 免疫学 神经科学 医学 病理 癌症 遗传学 基因 生物化学 古生物学
作者
Ilio Vitale,Federico Pietrocola,Emma Guilbaud,Stuart A. Aaronson,John Abrams,Dieter Adam,Massimiliano Agostini,Patrizia Agostinis,Emad S. Alnemri,Lucia Altucci,Ivano Amelio,David W. Andrews,Rami I. Aqeilan,Eli Arama,Eric H. Baehrecke,Siddharth Balachandran,Daniele Bano,Nickolai A. Barlev,Jiří Bártek,Nicolás G. Bazán,Christoph Becker,Francesca Bernassola,Mathieu Bertrand,Marco E. Bianchi,Mikhail V. Blagosklonny,J. Magarian Blander,Giovanni Blandino,Klas Blomgren,Christoph Borner,Carl D. Bortner,Pierluigi Bove,Patricia Boya,Catherine Brenner,Petr Brož,Thomas Brunner,Rune Busk Damgaard,George A. Calin,Michelangelo Campanella,Eleonora Candi,Michele Carbone,Didac Carmona‐Gutierrez,Francesco Cecconi,Francis K-M Chan,Guoqiang Chen,Quan Chen,Youhai H. Chen,Emily H. Cheng,Jerry E. Chipuk,John A. Cidlowski,Aaron Ciechanover,Gennaro Ciliberto,Marcus Conrad,Juan R. Cubillos-Ruiz,P.E. Czabotar,Vincenzo D’Angiolella,Mads Daugaard,Ted M. Dawson,Valina L. Dawson,Ruggero De Maria,Bart De Strooper,Klaus‐Michael Debatin,Ralph J. DeBerardinis,Alexei Degterev,Giannino Del Sal,Mohanish Deshmukh,Francesco Di Virgilio,Marc Diederich,Scott J. Dixon,Brian David Dynlacht,Wafik S. El‐Deiry,John W. Elrod,Kurt Engeland,Gian María Fimia,Claudia Galassi,Carlo Ganini,Ana J. García‐Sáez,Abhishek Garg,Carmen Garrido,Evripidis Gavathiotis,Motti Gerlic,Sourav Ghosh,Douglas R. Green,Lloyd A. Greene,Hinrich Gronemeyer,Georg Häcker,György Hajnóczky,J. Marie Hardwick,Ygal Haupt,Sudan He,David M. Heery,Michael O. Hengartner,Claudio Hetz,David Hildeman,Hidenori Ichijo,Satoshi Inoue,Marja Jäättelä,Ana Janic,Bertrand Joseph,Philipp J. Jost,Thirumala‐Devi Kanneganti,Michael Karin,Hamid Kashkar,Thomas Kaufmann,Gemma L. Kelly,Oliver Kepp,Adi Kimchi,Richard N. Kitsis,Daniel J. Klionsky,Ruth Kluck,Dmitri V. Krysko,Dagmar Kulms,Sharad Kumar,Sergio Lavandero,Inna N. Lavrik,John J. Lemasters,Gianmaria Liccardi,Andreas Linkermann,Stuart A. Lipton,Richard A. Lockshin,Carlos López‐Otín,Tom Luedde,Marion MacFarlane,Frank Madeo,Walter Malorni,Gwenola Manic,Roberto Mantovani,Saverio Marchi,Jean-Christophe Marine,Séamus J. Martin,Jean‐Claude Martinou,Pier G. Mastroberardino,Jan Paul Medema,Patrick Mehlen,Pascal Meier,Gerry Melino,Sonia Melino,Edward A. Miao,Ute M. Moll,Cristina Muñoz-Pinedo,Daniel J. Murphy,Maria Victoria Niklison-Chirou,Flavia Novelli,Gabriel Núñez,Andrew Oberst,Dimitry Ofengeim,Joseph T. Opferman,Moshe Oren,Michele Pagano,Theocharis Panaretakis,Manolis Pasparakis,Josef Penninger,Francesca Pentimalli,Paula B. Andrade,Shazib Pervaiz,Marcus E. Peter,Paolo Pinton,Giovanni Porta,Jochen H. M. Prehn,Hamsa Puthalakath,Gabriel A. Rabinovich,Krishnaraj Rajalingam,Kodi S. Ravichandran,Markus Rehm,Jean-Ehrland Ricci,Rosario Rizzuto,Nirmal Robinson,C.M.P. Rodrigues,Barak Rotblat,Carla V. Rothlin,David C. Rubinsztein,Thomas Rudel,Alessandro Rufini,Kevin M. Ryan,Kristopher A. Sarosiek,Akira Sawa,Emre Sayan,Kate Schroder,Luca Scorrano,Federico Sesti,Feng Shao,Yufang Shi,Giuseppe Sica,John Silke,Hans‐Uwe Simon,Antonella Sistigu,Anastasis Stephanou,Brent R. Stockwell,Flavie Strapazzon,Andreas Strasser,Liming Sun,Erwei Sun,Qiang Sun,György Szabadkai,Stephen W.G. Tait,Daolin Tang,Nektarios Tavernarakis,Carol M. Troy,Boris Turk,Nicoletta Urbano,Peter Vandenabeele,Tom Vanden Berghe,Matthew G Vander Heiden,Jacqueline L. Vanderluit,Alexei Verkhratsky,Andreas Villunger,Silvia von Karstedt,Anne Voss,Karen H. Vousden,Domagoj Vucic,Daniela Vuri,Erwin F. Wagner,Henning Walczak,David Wallach,Ruoning Wang,Ying Wang,Achim Weber,Will Wood,Takahiro Yamazaki,Huang‐Tian Yang,Zahra Zakeri,Joanna Zawacka-Pankau,Lin Zhang,Haibing Zhang,Boris Zhivotovsky,Wenzhao Zhou,Mauro Piacentini,Guido Kroemer,Lorenzo Galluzzi
出处
期刊:Cell Death & Differentiation [Springer Nature]
卷期号:30 (5): 1097-1154 被引量:67
标识
DOI:10.1038/s41418-023-01153-w
摘要

Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis in mammalian systems have elucidated the key contribution of this process not only to (post-)embryonic development and adult tissue homeostasis, but also to the etiology of multiple human disorders. Consistent with this notion, while defects in the molecular machinery for apoptotic cell death impair organismal development and promote oncogenesis, the unwarranted activation of apoptosis promotes cell loss and tissue damage in the context of various neurological, cardiovascular, renal, hepatic, infectious, neoplastic and inflammatory conditions. Here, the Nomenclature Committee on Cell Death (NCCD) gathered to critically summarize an abundant pre-clinical literature mechanistically linking the core apoptotic apparatus to organismal homeostasis in the context of disease.
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