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Value of Comprehensive Rehabilitation Therapy in Patients with Chronic Obstructive Pulmonary Disease and its Effect on Improving Inflammation.

医学 肺活量 恶化 慢性阻塞性肺病 康复 物理疗法 生活质量(医疗保健) 肺康复 内科学 日常生活活动 萧条(经济学) 评定量表 不利影响 肺功能测试 肺功能 心理学 扩散能力 经济 护理部 宏观经济学 发展心理学
作者
Zheng Li,Xuesong Yan,Jin Liu,Xinliang Feng,Xiangyun Li
出处
期刊:PubMed 卷期号:29 (4): 170-176 被引量:1
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To investigate the value of comprehensive rehabilitation therapy in chronic obstructive pulmonary disease (COPD) and its effect on improvement in patients' inflammation.A total of 174 patients with acute COPD exacerbation in the Affiliated Hospital of Hebei University in China from March 2020 to January 2022 were selected as research subjects. They were divided into control, acute and stable groups according to the random number table method (n=58 in each group). The control group was given conventional treatment; the acute group started comprehensive rehabilitation treatment in the acute phase; in the stable group, comprehensive rehabilitation treatment was initiated in the stable period after the condition was stabilized with conventional treatment. Tumor necrosis factor-α (TNF-α), high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6) and pulmonary function were measured before and after treatment, with the forced expiratory volume in 1 second (FEV1), forced expiratory volume in 1 second/forced vital capacity (FEV1/FVC) ratio, and peak expiratory flow rate (PEF). A 6-min walk test (6MWD) was performed on the patient, and the ability to perform activities of daily living (ADL), self-rating anxiety scale (SAS) and self-rating depression scale (SDS) were used to assess patients' ability to perform ADL and psychology. Finally, the incidence of adverse events (AEs) in patients was recorded and a quality of life (QoL) survey was completed.The 6MWD test, ADL, FEV1, FEV1/FVC and PEF were elevated in the acute and stable groups compared with the control group, whereas shortness of breath, TNF-α, hs-CRP and IL-6 were decreased (P < .05). SAS and SDS scores were reduced in the acute and stable groups after treatment (P < .05), while there was no change in the control group (P > .05). In addition, QoL was higher in the acute and stable groups (P < .05). The improvement of all indicators in the acute group was better than in the stable group (P < .05).Comprehensive rehabilitation therapy can improve the exercise capacity and lung function of patients with COPD, reduce inflammation, and improve patients' negative psychology.

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