Factors affecting continuous renal replacement therapy duration in critically ill patients: A retrospective study

Abstract Introduction This study aimed to analyze the factors affecting continuous renal replacement therapy (CRRT) duration in critically ill patients and provide a reference for clinical treatment. Material and Methods We divided patients into regional citrate anti‐coagulation (RCA) and low‐molecular‐weight‐heparin (LMWH) groups according to the anti‐coagulation method and collected the relevant data, to analyze the factors associated with CRRT time. Results Compared with the LMWH group, the RCA group had a longer mean treatment time (55.36 ± 22.57 vs. 37.65 ± 27.09 h, p < 0.001), lower transmembrane pressure, and lower filter pressure, regardless of vascular access site. Multivariable linear regression analysis showed a significant correlation between anti‐coagulation patterns, filter pressure at CRRT discontinuation, nurses' level of intensive care unit experience, pre‐machine fibrinogen level, and CRRT time. Conclusion Anti‐coagulation is the most important factor affecting CRRT duration. Filter pressure, nurses' level of intensive care unit experience, and fibrinogen level also affecting CRRT duration.