高脂血症
机制(生物学)
甘油三酯
药理学
胆固醇
生物化学
脂质代谢
化学
医学
糖尿病
内分泌学
认识论
哲学
作者
Liuyi Wei,Hao Wu,Xufeng Wang,Wen Li,Bo Cui,Yunhui Cheng
标识
DOI:10.1016/j.foodchem.2024.140715
摘要
Hyperlipidemia, an elevated level of cholesterol and/or triglycerides, has become a major public health problem worldwide. Although drugs intervention is effective in treating hyperlipidemia, most of them have adverse side effects. Peptides from natural plants with high anti-hyperlipidemic activity and a strong safety profile have emerged as promising candidates to prevent and ameliorate hyperlipidemia. This review summarizes the recent advances in plant-derived anti-hyperlipidemic peptides in terms of their sources, production, purification, identification, and activity evaluation. The focus is extended to their potential anti-hyperlipidemic mechanisms and structure-function relationships. Bioactive peptides derived from various plant sources, especially peptides containing hydrophobic and/or acidic amino acids, have shown remarkable effects in hyperlipidemic treatment. Their anti-hyperlipidemic effects are mediated by various mechanisms, including regulation of cholesterol metabolism and triglyceride metabolism, inhibition of inflammation-related metabolic syndrome, and modulation of the gut microbiota. Further evaluation of the stability, bioavailability, and clinical efficacy of these peptides is recommended.
科研通智能强力驱动
Strongly Powered by AbleSci AI