Gene expression and brain imaging association study reveals gene signatures in major depressive disorder

基因 重性抑郁障碍 情感(语言学) 生物 基因表达 遗传学 萧条(经济学) 灰质 心理学 神经科学 医学 白质 扁桃形结构 磁共振成像 宏观经济学 沟通 放射科 经济
作者
Wei Liu,Jianya Su,Ling‐Li Zeng,Hui Shen,Dewen Hu
出处
期刊:Brain communications [Oxford University Press]
标识
DOI:10.1093/braincomms/fcae258
摘要

Abstract Major depressive disorder is often characterized by changes in the structure and function of the brain, which are influenced by modifications in gene expression profiles. How the depression-related genes work together within the scope of time and space to cause pathological changes remains unclear. By integrated the brainwide gene expression data and imaging data in major depressive disorder, we identified gene signatures of major depressive disorder and explored their temporal-spatial expression specificity, network properties, function annotations and sex differences systematically. Based on correlation analysis with permutation testing, we found 345 depression-related genes significantly correlated with functional and structural alteration of brain images in major depressive disorder and separated them by directional effects. The genes with negative affect for grey matter density and positive affect for functional indices are enriched in down-regulated genes in the postmortem brain samples of depression patients and risk genes identified by genome-wide association studies than genes with positive affect for grey matter density and negative affect for functional indices and control genes, confirming their potential association with major depressive disorder. By introducing a parameter of dispersion measure on the gene expression data of developing human brains, we revealed higher spatial specificity and lower temporal specificity of depression-related genes than control genes. Meanwhile, we found depression-related genes tend to be more highly expressed in females than males, which may contribute to the difference in incidence rate between male and female patients. In general, we found the genes with negative affect have lower network degree, more specialized function, higher spatial specificity, lower temporal specificity, and more sex differences than genes with positive affect, indicating they may play different roles in the occurrence and development of major depressive disorder. These findings can enhance the understanding of molecular mechanisms underlying major depressive disorder and help develop tailored diagnostic and treatment strategies for depression patients of different sex.
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