Gene expression and brain imaging association study reveals gene signatures in major depressive disorder

基因 重性抑郁障碍 情感(语言学) 生物 基因表达 遗传学 萧条(经济学) 灰质 心理学 神经科学 医学 白质 扁桃形结构 磁共振成像 宏观经济学 沟通 放射科 经济
作者
Wei Liu,Jianya Su,Ling‐Li Zeng,Hui Shen,Dewen Hu
出处
期刊:Brain communications [Oxford University Press]
标识
DOI:10.1093/braincomms/fcae258
摘要

Abstract Major depressive disorder is often characterized by changes in the structure and function of the brain, which are influenced by modifications in gene expression profiles. How the depression-related genes work together within the scope of time and space to cause pathological changes remains unclear. By integrated the brainwide gene expression data and imaging data in major depressive disorder, we identified gene signatures of major depressive disorder and explored their temporal-spatial expression specificity, network properties, function annotations and sex differences systematically. Based on correlation analysis with permutation testing, we found 345 depression-related genes significantly correlated with functional and structural alteration of brain images in major depressive disorder and separated them by directional effects. The genes with negative affect for grey matter density and positive affect for functional indices are enriched in down-regulated genes in the postmortem brain samples of depression patients and risk genes identified by genome-wide association studies than genes with positive affect for grey matter density and negative affect for functional indices and control genes, confirming their potential association with major depressive disorder. By introducing a parameter of dispersion measure on the gene expression data of developing human brains, we revealed higher spatial specificity and lower temporal specificity of depression-related genes than control genes. Meanwhile, we found depression-related genes tend to be more highly expressed in females than males, which may contribute to the difference in incidence rate between male and female patients. In general, we found the genes with negative affect have lower network degree, more specialized function, higher spatial specificity, lower temporal specificity, and more sex differences than genes with positive affect, indicating they may play different roles in the occurrence and development of major depressive disorder. These findings can enhance the understanding of molecular mechanisms underlying major depressive disorder and help develop tailored diagnostic and treatment strategies for depression patients of different sex.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
十四阙发布了新的文献求助10
1秒前
T拐拐发布了新的文献求助10
3秒前
田野完成签到,获得积分10
3秒前
CodeCraft应助D1Yt采纳,获得10
6秒前
顾矜应助勤劳的汉堡采纳,获得10
10秒前
星辰大海应助coconut采纳,获得10
11秒前
壮观的远侵完成签到,获得积分10
12秒前
13秒前
15秒前
默默的小蚂蚁完成签到,获得积分10
15秒前
dd完成签到,获得积分10
15秒前
得己完成签到 ,获得积分10
16秒前
Orange应助大吉岭采纳,获得10
16秒前
Zorion发布了新的文献求助10
17秒前
yueya发布了新的文献求助50
17秒前
D1Yt发布了新的文献求助10
17秒前
21秒前
22秒前
22秒前
未来可期完成签到,获得积分20
25秒前
南明完成签到,获得积分10
25秒前
拼搏惜金完成签到,获得积分10
25秒前
duckweedyan完成签到,获得积分10
25秒前
26秒前
coconut发布了新的文献求助10
27秒前
甜甜戎发布了新的文献求助10
27秒前
28秒前
NexusExplorer应助悦耳白山采纳,获得10
28秒前
29秒前
29秒前
xx完成签到,获得积分10
30秒前
南明发布了新的文献求助10
30秒前
jklwss完成签到,获得积分10
31秒前
35秒前
37秒前
38秒前
my完成签到,获得积分10
38秒前
Ava应助lyy采纳,获得10
39秒前
跋扈完成签到,获得积分10
40秒前
枝枝江发布了新的文献求助10
41秒前
高分求助中
Production Logging: Theoretical and Interpretive Elements 2700
Les Mantodea de Guyane Insecta, Polyneoptera 1000
Structural Load Modelling and Combination for Performance and Safety Evaluation 1000
Conference Record, IAS Annual Meeting 1977 820
England and the Discovery of America, 1481-1620 600
電気学会論文誌D(産業応用部門誌), 141 巻, 11 号 510
Exploring the effects of an evidenced-based professional development programme on teaching and learning in Chinese kindergartens 500
热门求助领域 (近24小时)
化学 材料科学 生物 医学 工程类 有机化学 生物化学 物理 纳米技术 计算机科学 内科学 化学工程 复合材料 基因 遗传学 物理化学 催化作用 量子力学 光电子学 冶金
热门帖子
关注 科研通微信公众号,转发送积分 3576634
求助须知:如何正确求助?哪些是违规求助? 3146582
关于积分的说明 9465813
捐赠科研通 2848133
什么是DOI,文献DOI怎么找? 1565465
邀请新用户注册赠送积分活动 733041
科研通“疑难数据库(出版商)”最低求助积分说明 719546