炎症
消炎药
先天免疫系统
疾病
类风湿性关节炎
体内
无脊椎动物
生物
医学
免疫学
计算生物学
免疫系统
生物技术
生态学
病理
作者
Yikang Qiu,Shi-Ji Chen,Miao Yu,Jueying Shi,Jiayu Liu,Xiaoyang Li,Jiaxing Chen,Xue-Ping Sun,Guo-Lei Huang,Cai‐Juan Zheng
出处
期刊:Marine Drugs
[Multidisciplinary Digital Publishing Institute]
日期:2024-09-25
卷期号:22 (10): 433-433
被引量:4
摘要
Inflammation is considered as one of the most primary protective innate immunity responses, closely related to the body’s defense mechanism for responding to chemical, biological infections, or physical injuries. Furthermore, prolonged inflammation is undesirable, playing an important role in the development of various diseases, such as heart disease, diabetes, Alzheimer’s disease, atherosclerosis, rheumatoid arthritis, and even certain cancers. Marine-derived fungi represent promising sources of structurally novel bioactive natural products, and have been a focus of research for the development of anti-inflammatory drugs. This review covers secondary metabolites with anti-inflammatory activities from marine-derived fungi, over the period spanning August 2018 to July 2024. A total of 285 anti-inflammatory metabolites, including 156 novel compounds and 11 with novel skeleton structures, are described. Their structures are categorized into five categories: terpenoids, polyketides, nitrogen-containing compounds, steroids, and other classes. The biological targets, as well as the in vitro and in vivo screening models, were surveyed and statistically summarized. This paper aims to offer valuable insights to researchers in the exploration of natural products and the discovery of anti-inflammatory drugs.
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