Arrest and repair of inflammatory root resorption after an endodontic regeneration procedure – a hypothesis and case report

External Inflammatory Root Resorption (EIRR) is a significant complication that can occur following traumatic dental injuries, with a prevalence of approximately 18%. Most cases occur during the early stage of the mixed dentition. Specifically, EIRR occurs in approximately 5-8% of luxation injuries, 30% of replanted teeth following avulsion, and 38% of intruded teeth. Conventional methods for addressing EIRR in immature teeth pose several challenges. This often requires numerous dental visits where Ledermix® and calcium hydroxide are used, which may significantly prolong the treatment. Additionally, the effect of prolonged use of calcium hydroxide medication in the root canal is debatable. Recent publications have highlighted the ability of regenerative endodontic treatment (RET) to effectively stop and repair external inflammatory root resorption (EIRR) in a relatively brief time, yielding impressive results. Nevertheless, the underlying mechanism responsible for this effect remains unclear.