1.10 Nickel-Catalyzed Cross-Electrophile Coupling Reactions

Abstract Nickel-catalyzed cross-electrophile coupling has become a powerful tool for the construction of molecules. These new bond-forming reactions bypass the requirement for the handling of organometallic reagents and are selectively orthogonal to classic cross couplings. This chapter provides a brief review of the achievements in this field. Selected methods for C—C coupling with a variety of reacting partners are presented. In addition to transformations involving a metal reductant, representative examples of nickel metallaphotocatalysis and electrochemical nickel catalysis are also discussed. Finally, expansion of this chemistry to the reactions of heavier group 14 electrophiles is described.