衣康酸
壳聚糖
自愈水凝胶
肿胀 的
材料科学
药物输送
表征(材料科学)
化学工程
聚丙烯酰胺
高分子化学
傅里叶变换红外光谱
动力学
水溶液
丙烯酰胺
聚合物
共聚物
复合材料
纳米技术
工程类
物理
量子力学
作者
A. Martínez-Ruvalcaba,J. C. Sánchez-Díaz,F. Becerra,Luis Emilio Cruz-Barba,Alejandro González-Álvarez
出处
期刊:Express Polymer Letters
[Department of Polymer Engineering Budapest University of Technology & Economics), Scientific Society of Mechanical Engineerin]
日期:2009-01-01
卷期号:3 (1): 25-32
被引量:119
标识
DOI:10.3144/expresspolymlett.2009.5
摘要
Hybrid polymeric networks composed of polyacrylamide and chitosan were developed to determine their swelling and ascorbic acid delivery kinetics at various chitosan concentrations. The hybrid acrylamide/chitosan hydrogels were synthesized in aqueous itaconic acid solution (1% w/w). Young’s modulus was also evaluated for the hydrogels, and the results were correlated with the swelling properties. Swelling experiments were carried out using three different pH solutions: acidic (pH 4 buffer solution), neutral (distilled water) and basic (pH 10 buffer solution). The results of the swelling study showed that the swelling properties of the network varied with the changes of the pH in the swelling solution, as well as concentration of chitosan. When chitosan concentration increased, the swelling capacity diminished, and therefore Young’s modulus increased. The results indicated that the swelling process followed a second order kinetics. The ascorbic acid diffusion inside the hydrogel follows a Fickian mechanism. The ascorbic acid diffusion coefficients are reported as a function of chitosan concentration.
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