TEMPO-Mediated Oxidation of Primary Alcohols to Carboxylic Acids by Exploitation of Ethers in an Aqueous–Organic Biphase System

Abstract Expeditious and benign methods for primary alcohol–carboxylic acid conversions with TEMPO were developed in a biphasic system composed of a slightly miscible ether (THP) and aqueous layer. Easily available co-oxidants such as Py·HBr3, Bu4NBr3, and electrooxidation were successfully applied to generate N-oxoammonium species as a recyclable catalyst.