巨头畸形
病理
医学
白质脑病
白质营养不良
脊髓
脑干
萎缩
疾病
中枢神经系统疾病
内科学
精神科
作者
Marjo S. van der Knaap,Venkateswari Ramesh,Raphael Schiffmann,Susan Blasér,M. Kyllerman,A. Gholkar,David W. Ellison,J. Patrick van der Voorn,Silvy J.M. van Dooren,Cornelis Jakobs,Frederik Barkhof,Gajja S. Salomons
出处
期刊:Neurology
[Ovid Technologies (Wolters Kluwer)]
日期:2006-02-27
卷期号:66 (4): 494-498
被引量:136
标识
DOI:10.1212/01.wnl.0000198770.80743.37
摘要
Alexander disease is most commonly associated with macrocephaly and, on MRI, a leukoencephalopathy with frontal preponderance. The disease is caused by mutation of the GFAP gene. Clinical and MRI phenotypic variation have been increasingly recognized.The authors studied seven patients with Alexander disease, diagnosed based on mutations in the GFAP gene, who presented unusual MRI findings. The authors reviewed clinical history, MRI abnormalities, and GFAP mutations.All patients had juvenile disease onset with signs of brainstem or spinal cord dysfunction. None of the patients had a macrocephaly. The MRI abnormalities were dominated by medulla and spinal cord abnormalities, either signal abnormalities or atrophy. One patient had only minor cerebral white matter abnormalities. A peculiar finding was the presence of a kind of garland along the ventricular wall in four patients. Three patients had an unusual GFAP mutation, one of which was a duplication mutation of two amino acids, and one an insertion deletion.Signal abnormalities or atrophy of the medulla or spinal cord on MRI are sufficient to warrant DNA analysis for Alexander disease. Ventricular garlands constitute a new sign of the disease. Unusual phenotypes of Alexander disease are found among patients with late onset and protracted disease course.
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