DNA糖基化酶
穆提
基底切除修复术
DNA损伤
DNA修复
鸟嘌呤
DNA
化学
生物
生物化学
基因
核苷酸
作者
Sheila S. David,Valerie L. O’Shea,Sucharita Kundu
出处
期刊:Nature
[Springer Nature]
日期:2007-06-01
卷期号:447 (7147): 941-950
被引量:1151
摘要
Maintaining the chemical integrity of DNA in the face of assault by oxidizing agents is a constant challenge for living organisms. Base-excision repair has an important role in preventing mutations associated with a common product of oxidative damage to DNA, 8-oxoguanine. Recent structural studies have shown that 8-oxoguanine DNA glycosylases use an intricate series of steps to locate and excise 8-oxoguanine lesions efficiently against a high background of undamaged bases. The importance of preventing mutations associated with 8-oxoguanine is shown by a direct association between defects in the DNA glycosylase MUTYH and colorectal cancer. The properties of other guanine oxidation products and the associated DNA glycosylases that remove them are now also being revealed.
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