第二信使系统
受体
细胞内
主题(音乐)
细胞生物学
生物
化学
生物化学
物理
声学
作者
Shen Xianrong,Wenbing Tao,Jilie Kong,Shaoning Yu
标识
DOI:10.1016/j.ijbiomac.2008.01.006
摘要
Cyclic AMP serves as an intracellular messenger in cells and regulates a variety of biological functions by transmitting information through proteins. These proteins of different functions all consist of a cAMP-binding motif, and the structure of this motif is highly conserved with an exception of the loop 3 and 4. In current study, cAMP receptor protein was employed as a model system to investigate the function of the two loops. The results indicated that the loop 3 involves in the intersubunits communication of CRP, whereas the loop 4 involves in cAMP binding and interdomains communication.
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