抗生素
细菌
生物
微生物学
基因
抗生素耐药性
微生物遗传学
水平基因转移
抗药性
致病菌
细菌遗传学
氯霉素
人口
氨基糖苷
遗传学
大肠杆菌
基因组
医学
环境卫生
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:1994-04-15
卷期号:264 (5157): 375-382
被引量:1737
标识
DOI:10.1126/science.8153624
摘要
The emergence of multidrug-resistant bacteria is a phenomenon of concern to the clinician and the pharmaceutical industry, as it is the major cause of failure in the treatment of infectious diseases. The most common mechanism of resistance in pathogenic bacteria to antibiotics of the aminoglycoside, β-lactam (penicillins and cephalosporins), and chloramphenicol types involves the enzymic inactivation of the antibiotic by hydrolysis or by formation of inactive derivatives. Such resistance determinants most probably were acquired by pathogenic bacteria from a pool of resistance genes in other microbial genera, including antibiotic-producing organisms. The resistance gene sequences were subsequently integrated by site-specific recombination into several classes of naturally occurring gene expression cassettes (typically "integrons") and disseminated within the microbial population by a variety of gene transfer mechanisms. Although bacterial conjugation once was believed to be restricted in host range, it now appears that this mechanism of transfer permits genetic exchange between many different bacterial genera in nature.
科研通智能强力驱动
Strongly Powered by AbleSci AI