促炎细胞因子
炎症
生物
NF-κB
趋化因子
信号转导
NFKB1型
细胞生物学
免疫学
转录因子
圣杯
基因
遗传学
计算机科学
万维网
出处
期刊:Cold Spring Harbor Perspectives in Biology
[Cold Spring Harbor Laboratory]
日期:2009-10-07
卷期号:1 (6): a001651-a001651
被引量:3436
标识
DOI:10.1101/cshperspect.a001651
摘要
The nuclear factor NF-kappaB pathway has long been considered a prototypical proinflammatory signaling pathway, largely based on the role of NF-kappaB in the expression of proinflammatory genes including cytokines, chemokines, and adhesion molecules. In this article, we describe how genetic evidence in mice has revealed complex roles for the NF-kappaB in inflammation that suggest both pro- and anti-inflammatory roles for this pathway. NF-kappaB has long been considered the "holy grail" as a target for new anti-inflammatory drugs; however, these recent studies suggest this pathway may prove a difficult target in the treatment of chronic disease. In this article, we discuss the role of NF-kappaB in inflammation in light of these recent studies.
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