医学
冰冻切片程序
仁慈
置信区间
卵巢癌
诊断试验中的似然比
妇科
内科学
癌症
病理
恶性肿瘤
作者
Lídia Rosi Medeiros,Daniela Dornelles Rosa,Maria Isabel Albano Edelweiss,Airton Tetelbom Stein,Mary Clarisse Bozzetti,Alice Zelmanowicz,Paula R. Pohlmann,Luíse Meurer,Mariana Teixeira Carballo
出处
期刊:International Journal of Gynecological Cancer
[BMJ]
日期:2005-03-01
卷期号:15 (2): 192-202
被引量:82
标识
DOI:10.1111/j.1525-1438.2005.15203.x
摘要
A quantitative systematic review was performed to estimate the diagnostic accuracy of frozen sections in ovarian tumors. Studies that compared frozen sections and paraffin sections within subjects for diagnosis of ovarian tumors were included. Fourteen primary studies were analyzed, which included 3 659 women. For benign ovarian vs borderline/malignant tumor cases, the occurrence of a positive frozen-section result for benignity (pooled likelihood ratio [LR], 8.7; 95% confidence interval [CI], 7.3-10.4) and posttest probability for benign diagnosis was 95% (95% CI, 94-96%). A positive frozen-section result for malignant vs benign diagnosis (pooled LR, 303; 95% CI, 101-605) increased the probability of ovarian cancer to 98% (95% CI, 97-99%). In borderline vs benign ovarian tumor cases, a positive frozen-section result (pooled LR, 69; 95% CI, 45-106) increased the probability of borderline tumors to 79% (95% CI, 71-85%). In borderline vs malignant ovarian tumor cases, a positive frozen-section result (pooled LR, 18; 95% CI, 13-26) increased the probability of borderline tumors to 51% (95% CI, 42-60%). We conclude that diagnostic accuracy rates for frozen-section analysis is high for malignant and benign ovarian tumors, but the accuracy rates in borderline tumors remain relatively low.
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