Chemical constituents from Euphorbia stracheyi and their biological activities

Three new diterpenoids, stracheyioids A–C (1–3), as well as 36 known compounds (4–39) were isolated from the whole plants of Euphorbia stracheyi. Compound 1 was a rare 13-deoxy tigliane diterpenoid and compound 2 was an ingenol diterpenoid characterized by an unique 2Z,4Z-decadienoyl acidic moieties. All the known compounds were isolated from E. stracheyi for the first time. Their structures were elucidated on the basis of extensive spectroscopic interpretation. Compounds 1–39 were tested for their cytotoxicity against five cancer cell lines (A-549, MCF-7, Hep G2, Hela and P388) and showed IC50 values in the range 6.64–42.86 μM. The antiangiogenic activities of the isolated compounds were also evaluated using a zebrafish model.