口腔扁平苔藓
细胞毒性T细胞
病理
发病机制
抗原
生物
免疫系统
免疫组织化学
免疫学
单核细胞
巨噬细胞
口腔粘膜
医学
体外
生物化学
作者
Yasuhiro Takeuchi,Iwai Tohnai,T Kaneda,H Nagura
标识
DOI:10.1111/j.1600-0714.1988.tb01299.x
摘要
We immunohistochemically analyzed the immunological background of the pathogenesis of oral lichen planus (OLP). Abundant lymphocytes infiltrated OLP mucosal lesions, particularly in satellite cell necrosis (SCN) regions, and cytotoxic/suppressor T lymphocytes were predominant in seven of 10 OLP cases. Some carried IL‐2 receptors, particularly in SCN. Keratinocytes of the mucosal lesions expressed both HLA‐ABC and HLA‐DR antigens. This suggests that activated cytotoxic/suppressor T lymphocytes may play a major role in cytotoxity to keratinocytes as effector cells in OLP. OKM1‐, OKM5+, HLA‐DR+ and IL‐1+ cells, vascular endothelial cells and clusters of spindle‐shaped or oval cells, which had the same surface characteristics as a monocyte macrophage subset, were abundant and, together with migrating lymphocytes, might play a role in the immune response in mucosal lesions of OLP.
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