非典型溶血尿毒综合征
伊库利珠单抗
微血管病性溶血性贫血
医学
血栓性微血管病
血栓性血小板减少性紫癜
耐火材料(行星科学)
溶血性贫血
血小板
免疫学
单克隆
急性肾损伤
内科学
补体系统
胃肠病学
抗体
单克隆抗体
疾病
物理
天体生物学
作者
Rene S. Bermea,Niharika Sharma,Kenneth J. Cohen,Vladimir M. Liarski
出处
期刊:Jcr-journal of Clinical Rheumatology
[Ovid Technologies (Wolters Kluwer)]
日期:2016-09-01
卷期号:22 (6): 320-323
被引量:10
标识
DOI:10.1097/rhu.0000000000000423
摘要
Abstract Atypical hemolytic uremic syndrome is characterized by the presence of thrombocytopenia, microangiopathic hemolytic anemia, and end-organ injury. In this report, we describe two patients with systemic lupus erythematosus who presented with findings compatible with atypical hemolytic uremic syndrome, complicated by acute kidney injury that was refractory to conventional therapies. Both patients exhibited a response to eculizumab, a monoclonal antibody to complement protein C5, with stabilization of their platelet count. On 1-year follow-up from their initial presentation, their hematologic disease remained in remission without recurrence.
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