Cytokine Release Syndrome: Inpatient Care for Side Effects of CAR T-Cell Therapy

Chimeric antigen receptor (CAR) T-cell therapy is being used more often for pediatric patients with relapsed and refractory acute lymphoblastic leukemia (ALL). As with any new therapy, CAR T-cell therapy comes with a unique set of challenges for symptom management. Side effects can range from mild to severe. Mild side effects can be managed in an outpatient setting, and severe events with multisystem organ failure may require care in an intensive care unit (ICU).