Studies on Synthesis of a Novel, Broad-Spectrum Antitumor Compound 2-(1-hydroxy-4-oxo-cyclohexa-2, 5-dienyl)-pyran-4-one

Background: Based on the previous studies, used protoapigenone as a model, we adopted chemical synthesis methods to develop the new compounds. It was specifically named as 2-(1-hydroxy- 4-oxo-2, 5-cyclohexadien-1-yl)-4H-Pyran-4-one, including a core group: 1-hydroxycyclohexa-2, 5- dien-4-one. Through our research it significantly inhibited human gynecological tumor, prostate tumor, digestive system tumors and hematological tumors, but without affecting the normal hematopoietic system and immune system. Additionally, this compound can effectively inhibit tumor growth in H22 mice with tumor, while had no effect to peripheral blood leukocytes, ratio of peripheral blood granulocyte cell and lymphocyte, thymus index and spleen index. But the synthetic methods of the compound has been plaguing us and now we invent a new synthetic process of it. The present invention in this article provides the method capable of industrially producing the target product. Keywords: α, β-unsaturated ketones, 4H-pyran-4-ones, tumor growth inhibition.