Retinoblastoma Binding Protein 6, Another p53 Monitor

The retinoblastoma binding protein 6 (RBBP6), a p53 negative regulator, is essential for embryonic development. Its loss-of-function phenotype is similar to mouse double minute homolog (MDM2), the prototypical negative regulator of p53. This article draws attention to the molecular and biological functions of RBBP6 and to its association with carcinogenesis.