活性炭
卡马西平
地高辛
木炭
药理学
生理盐水
化学
医学
吸附
麻醉
内科学
有机化学
精神科
癫痫
心力衰竭
作者
M A Montoya-Cabrera,P Escalante-Galindo,Juan Manuel Sauceda-García,L M Márquez-Enríquez,H González-Cabello,Eduardo Flores-Álvarez
出处
期刊:PubMed
日期:1995-05-01
卷期号:131 (3): 349-54
被引量:1
摘要
Twelve pediatric patients with acute poisonings caused by carbamazepine, digoxin and acetylsalicylic acid were treated with multiple doses of activated charcoal combined with a saline cathartic (adsorption surface of activated charcoal nearly 950 m2/g). This procedure was effective to shorten the plasmatic levels of the drugs, besides the clinical improvement of the poisoned patients. The average initial and final levels of the drugs were: carbamazepine 21.64 and 0.9 micrograms/ml (lowering 95.81%, p < 0.05), digoxin 5.14 and 1.1 ng/ml (lowering 78.6%, P < 0.05) and acetylsalicylic acid 418.5 and 57.5 micrograms/ml, respectively, (lowering 86.3%, p < 0.05). These results suggest the usefulness of activated charcoal in the clearance of the four overdosed drugs.
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