Relationship of homocysteine, folic acid and vitamin B12 with depression in a middle-aged community sample

同型半胱氨酸 维生素B12 医学 内科学 高强度 肌酐 四分位数 萧条(经济学) 混淆 B族维生素 生理学 内分泌学 磁共振成像 置信区间 宏观经济学 经济 放射科
作者
Perminder S. Sachdev,Ruth Parslow,Ora Lux,Chris Salonikas,Wei Wen,Daya Naidoo,Helen Christensen,Anthony F. Jorm
出处
期刊:Psychological Medicine [Cambridge University Press]
卷期号:35 (4): 529-538 被引量:132
标识
DOI:10.1017/s0033291704003721
摘要

Case control studies have supported a relationship between low folic acid and vitamin B112 and high homocysteine levels as possible predictors of depression. The results from epidemiological studies are mixed and largely from elderly populations.A random subsample of 412 persons aged 60-64 years from a larger community sample underwent psychiatric and physical assessments, and brain MRI scans. Subjects were assessed using the PRIME-MD Patient Health Questionnaire for syndromal depression and severity of depressive symptoms. Blood measures included serum folic acid, vitamin B12, homocysteine and creatinine levels, and total antioxidant capacity. MRI scans were quantified for brain atrophy, subcortical atrophy, and periventricular and deep white-matter hyperintensity on T2-weighted imaging.Being in the lowest quartile of homocysteine was associated with fewer depressive symptoms, after adjusting for sex, physical health, smoking, creatinine, folic acid and B12 levels. Being in the lowest quartile of folic acid was associated with increased depressive symptoms, after adjusting for confounding factors, but adjustment for homocysteine reduced the incidence rate ratio for folic acid to a marginal level. Vitamin B12 levels did not have a significant association with depressive symptoms. While white-matter hyperintensities had significant correlations with both homocysteine and depressive symptoms, the brain measures and total antioxidant capacity did not emerge as significant mediating variables.Low folic acid and high homocysteine, but not low vitamin B12 levels, are correlates of depressive symptoms in community-dwelling middle-aged individuals. The effects of folic acid and homocysteine are overlapping but distinct.

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