医学
右美托咪定
麻醉
镇静
安慰剂
脑电双频指数
镇静剂
止痛药
鼻腔给药
耐受性
不利影响
内科学
病理
免疫学
替代医学
作者
Nasser Nooh,Saad A. Sheta,Walid Abdullah,Ashraf Arafat Abdelhalim
标识
DOI:10.1016/j.ijom.2013.02.003
摘要
Abstract
The purpose of this study was to evaluate the intranasal use of 1.5μg/kg atomized dexmedetomidine for sedation in patients undergoing mandibular third molar removal. Eighteen patients underwent third molar removal in two surgical sessions. Patients were randomly assigned to receive intranasal water (placebo group) or 1.5μg/kg atomized dexmedetomidine (group D) at the first session. The alternate regimen was used during the second session. Local anaesthesia was injected 30min after placebo/sedative administration. Pain from local anaesthesia infiltration was rated on a scale from zero (no pain) to 10 (worst pain imaginable). Sedation status was measured every 10min by a blinded observer with a modified Observer's Assessment of Alertness/Sedation (OAA/S) scale and the bispectral index (BIS). Adverse reactions and analgesic consumption were recorded. Sedation values in group D were significantly different from placebo at 20–30min, peaked at 40–50min, and returned to placebo levels at 70–80min after intranasal drug administration. Group D displayed decreased heart rate and systolic blood pressure, but the decreases did not exceed 20% of the baseline values. Intranasal administration of 1.5μg/kg atomized dexmedetomidine is effective, convenient, and safe as a sedative for patients undergoing third molar extraction.
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