The complete family of epidermal growth factor receptors and their ligands are co-ordinately expressed in breast cancer

安非雷古林 神经调节蛋白 皮调节素 神经调节蛋白1 乳腺癌 表皮生长因子 生物 表皮生长因子受体 受体 内科学 ERBB4公司 癌症 内分泌学 医学 受体酪氨酸激酶
作者
Emmet McIntyre,E. K. Blackburn,Philip J. Brown,Colin G. Johnson,William J. Gullick
出处
期刊:Breast Cancer Research and Treatment [Springer Science+Business Media]
卷期号:122 (1): 105-110 被引量:42
标识
DOI:10.1007/s10549-009-0536-5
摘要

The levels of expression of the four receptors and eleven ligands composing the epidermal growth factor family were measured using immunohistochemical staining in one hundred cases of breast cancer. All of the family were expressed to some degree in some cases; however, individual cases showed a very wide range of expression of the family from essentially none to all the factors at high levels. The highest aggregate level of expression of a receptor was HER2 followed by HER1, then HER3, then HER4. The ligands (including two splice variants of the NRG1 and NRG2 genes) broadly fell into three groups, those with the highest aggregate expression were Epigen, Epiregulin, Neuregulin 1α, Neuregulin 2α, Neuregulin 2β, Neuregulin 4 and TGFα, moderate expression was seen with EGF, Neuregulin 1β and Neuregulin 3, and relatively low levels of expression were seen of HB-EGF, Betacellulin and Amphiregulin. Statistical analysis using Spearman’s Rank Correlation showed a positive correlation of expression between each of the factors. Analysing the data using the Cox Proportional Hazards model showed that, in this dataset, the most powerful predictors of relapse free interval and overall survival were the combined measurement of only Epigen and Neuregulin 4.
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