肿瘤微环境
背景(考古学)
间质细胞
癌症
肿瘤进展
生物
可塑性
免疫系统
癌细胞
癌症研究
免疫学
遗传学
古生物学
物理
热力学
作者
Zvi Granot,Zvi G. Fridlender
出处
期刊:Cancer Research
[American Association for Cancer Research]
日期:2015-11-01
卷期号:75 (21): 4441-4445
被引量:80
标识
DOI:10.1158/0008-5472.can-15-1502
摘要
Abstract Tumor initiation, growth, and metastatic progression are complex processes that, in order to be successful, require extraordinary cellular plasticity. Accordingly, tumor cell plasticity and how it affects disease progression have been studied extensively. However, as our understanding of the tumor microenvironment deepens, we are confronted with the notion that functional plasticity in the context of cancer is not limited to tumor cells alone but is also commonly seen in normal stromal cells of the microenvironment, and specifically in immune cells. Here, we review the functional plasticity these cells exhibit in the context of cancer, highlighting the role of circulating and tumor-associated neutrophils. We further discuss how this plasticity supports or limits tumor progression, inducing an “immunosuppressive switch” to promote further tumor growth and development. Cancer Res; 75(21); 4441–5. ©2015 AACR.
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